منابع مشابه
Interleukin 10 treatment for rheumatoid arthritis.
Interleukin (IL) 10 looms as a highly promising treatment for rheumatoid arthritis (RA) because of its capacity to inhibit cellular immunity and deactivate macrophages. In RA, activated CD4 T helper cells and macrophages are believed to be the primary driving force behind joint inflammation. Synovial macrophages play a critical part in stimulating synovial inflammation. They produce abundant qu...
متن کاملInterleukin-10 and Receptors in Treatment Rheumatoid Arthritis
The progressive destruction of cartilage and bone in rheumatoid arthritis(RA) cause substantial effects in the synovial membrane and, this is dangerous for rheumatoid arthritis patients, macrophages play a potent stimulating role in synovial inflammation. Accordingly, we purposed in this review to study both treatment of AR by interleukin 10 (IL-10), and receptors with signalization pathway IL-...
متن کاملImmunoregulatory role of interleukin 10 in rheumatoid arthritis
The presence and the role of interleukin 10 (IL-10), a potent cytokine synthesis inhibitory factor and antiinflammatory cytokine, were investigated in rheumatoid arthritis (RA). The expression of both mRNA and protein for IL-10 could be demonstrated in RA and osteoarthritis (OA) joints. Human IL-10 mRNA could be demonstrated by polymerase chain reaction amplification of cDNA made by reverse tra...
متن کاملPrevention of Arthritis by Interleukin 10–producing B Cells
In this study we have shown that activation of arthritogenic splenocytes with antigen and agonistic anti-CD40 gives raise to a B cell population that produce high levels of interleukin (IL)-10 and low levels of interferon (IFN)-gamma. Transfer of these B cells into DBA/1-TcR-beta-Tg mice, immunized with bovine collagen (CII) emulsified in complete Freund's adjuvant inhibited T helper type 1 dif...
متن کاملExpression of interleukin-10 family cytokines in rheumatoid arthritis
Background and aims: Interleukin-10 (IL-10) is an anti-inflammatory cytokine, and its expression is increased in rheumatoid arthritis (RA). A number of novel cytokines have been found recently, which have been designated as the IL-10 family based on their genetic characteristics. These cytokines include IL-19, IL-20, IL-22, IL-24 and IL-26. Information concerning the expression and function of ...
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ژورنال
عنوان ژورنال: Rheumatology
سال: 1999
ISSN: 1460-2172
DOI: 10.1093/rheumatology/38.4.293